It all begins with science.
What can cannabis help with?
The Green Genomix report is geared towards identifying optimal cannabinoid content, amount, and product type for the following six stand-alone health qualities:
Cannabinoids such as THC and CBD can have anxiolytic effects meaning they can alleviate anxiety and foster a calming mental state, particularly when taken in the correct amounts. THC and CBD each interact with the human endocannabinoid system, but in different ways which is why consuming the correct amount is so important.
The presence of certain genetic variants provide an indication as to how varying amounts of THC and CBD may affect one’s mental state. Genes such as the MYO16 gene indicate a predisposition for cannabis affinity (positive response to cannabis), and genes such as the AKT1 provide an indication for how likely one is to experience symptoms of psychosis such as anxiety.
Mood & Behavior
Cannabinoids have been known to have a positive and negative impact on mood and behavior. THC and CBD, both together and separately can alter one’s mood. It is only with the right amounts of THC and CBD that your mood and behavior can be improved.
Certain genetic variants provide insight into how one’s mood and behavior may change when consuming THC and CBD. Some individuals are genetically predisposed to a negative change in mood, others a positive change, and some to no change. Understanding and identifying these genetic predispositions enables one to determine which cannabinoid formulations will most likely prevent a negative change in mood and behavior and foster a positive change.
Cannabinoids have acute effects on working memory and concentration (cognition). For many people, cannabinoids can improve working memory and concentration and for others it can disrupt working memory and concentration. The effects can also be dose-dependent. The effects that cannabis has on working memory and concentration can range from severe to none.
Certain genetic variants have been known to provide insight into how an individual’s working memory and concentration may change when consuming THC and CBD. Understanding and identifying such variants enable us to determine which cannabinoid formulations and consumption methods will enhance one’s working memory and concentration or disrupt it.
THC and other psychoactive cannabinoids have been shown to decrease pain perception for some individuals. The human body has receptors in the endocannabinoid system that communicate with pain-regulating parts of the central nervous system. When certain cannabinoids are consumed these parts of the nervous system induce a change in pain perception.
There exist genetic variants that can predict how effectively, if at all, THC and CBD will reduce an individual's pain perception and thus make pain more manageable and less noticeable. Genes such as the OPRM1 and OPRD1 are related to the degree of change in pain perception when stimulated.
Metabolism in the context of cannabinoids relates to the rate at which one’s body processes cannabinoids. Learning about one’s cannabinoid metabolism can help predict how long the effects of cannabis will last. This is important because some people may require longer lasting effects for their specific ailment.
There exist specific genetic variants that enable us to predict how THC and CBD will be metabolized. These variants might be related directly to one’s endocannabinoid system or they may code for other biochemical features such as enzymes. There is a large degree of variation in these genes which is why metabolic rates differ among individuals.
Just because two people take the same dose does not mean they will experience the same intensity of effects. Understanding one’s sensitivity to cannabinoids can give an idea of what dose one should take based upon the effects they want to achieve.
There are certain genes that provide an indication regarding the amount of cannabinoid receptors throughout a person’s body. The greater the number of receptors, the higher one’s sensitivity to cannabinoids, and thus the more intense cannabinoids will be for that person.
Cannabinoids have been shown to have extremely positive effects on many individuals’ sleep quality. Some people experience improvements in sleep with THC, some with CBD, and others with both THC & CBD. As is the case with all cannabinoid-based effects, the cannabinoid-content and dose has a significant impact on the change in one’s sleep quality.
Certain genetic variants have been known to provide insight into how an individual’s sleep quality is affected when consuming THC and CBD. Understanding and identifying such predispositions enable us to determine which (if any) cannabinoid formulations and consumption methods will enhance one’s sleep quality.
Cannabinoids can have a significant impact on one’s energy levels. Although other variables such as exercise and sleep quality play a role in energy, cannabinoids can also contribute to increased and decreased energy over the period of a couple hours or even an entire day.
Certain genetic variants provide insight into how an individual’s energy levels can be changed by THC, CBD, and other cannabinoids/terpenes. Understanding and identifying such predispositions enable us to determine which (if any) cannabinoid formulations and consumption methods will enhance one’s energy or disrupt one’s energy.
Our process is holistic
Our process uses your genetics, previous experiences with cannabis, and lifestyle to create a more complete picture of how cannabinoids affect your body and mind.
Why are each of these important and how are they related?
Cannabinoid & terpenoid content being consumed. This includes the cannabinoid/terpenoid ratios, amounts, and delivery method. Different amounts of cannabinoids such as THC and CBD can have drastically different effects, especially when consumed varying concentrations of one another.
Lifestyle. Exercise consistency and intensity can affect how quickly one metabolizes cannabinoids, cannabis use frequency/amount can affect one's tolerance to cannabinoids, mood and behavior can provide context for how one may mentally respond to cannabinoids, and much more.
Genetic makeup. The genetic variants an individual possesses provide insight into the structure and functionality of their biological interior. Various features of an individual's biological interior such as the endocannabinoid system, certain metabolic pathways, the central nervous system, and more are responsible for many variables regarding one's experience with cannabis.
Looking for more technical information?
Check out the studies listed below that detail some of the science behind a couple of the genetic variants we test for and how they relate to cannabis.